MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection. Here, we investigate...

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Detalles Bibliográficos
Autores principales: Mielech, Anna M., Kilianski, Andy, Baez-Santos, Yahira M., Mesecar, Andrew D., Baker, Susan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957432/
https://www.ncbi.nlm.nih.gov/pubmed/24503068
http://dx.doi.org/10.1016/j.virol.2013.11.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957432/
https://www.ncbi.nlm.nih.gov/pubmed/24503068
http://dx.doi.org/10.1016/j.virol.2013.11.040

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