Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

GAK (cyclin G-associated kinase) is a key regulator of clathrin-coated vesicle trafficking and plays a central role during development. Additionally, due to the unusually high plasticity of its catalytic domain, it is a frequent ‘off-target’ of clinical kinase inhibitors associated with respiratory...

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Detalles Bibliográficos
Autores principales: Chaikuad, Apirat, Keates, Tracy, Vincke, Cécile, Kaufholz, Melanie, Zenn, Michael, Zimmermann, Bastian, Gutiérrez, Carlos, Zhang, Rong-guang, Hatzos-Skintges, Catherine, Joachimiak, Andrzej, Muyldermans, Serge, Herberg, Friedrich W., Knapp, Stefan, Müller, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957475/
https://www.ncbi.nlm.nih.gov/pubmed/24438162
http://dx.doi.org/10.1042/BJ20131399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957475/
https://www.ncbi.nlm.nih.gov/pubmed/24438162
http://dx.doi.org/10.1042/BJ20131399

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