Antibiotic Streptolydigin Requires Noncatalytic Mg(2+) for Binding to RNA Polymerase

Multisubunit RNA polymerase, an enzyme that accomplishes transcription in all living organisms, is a potent target for antibiotics. The antibiotic streptolydigin inhibits RNA polymerase by sequestering the active center in a catalytically inactive conformation. Here, we show that binding of streptol...

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Detalles Bibliográficos
Autores principales: Zorov, Savva, Yuzenkova, Yulia, Nikiforov, Vadim, Severinov, Konstantin, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957892/
https://www.ncbi.nlm.nih.gov/pubmed/24342645
http://dx.doi.org/10.1128/AAC.02248-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957892/
https://www.ncbi.nlm.nih.gov/pubmed/24342645
http://dx.doi.org/10.1128/AAC.02248-13

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