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Antibiotic Streptolydigin Requires Noncatalytic Mg(2+) for Binding to RNA Polymerase
Multisubunit RNA polymerase, an enzyme that accomplishes transcription in all living organisms, is a potent target for antibiotics. The antibiotic streptolydigin inhibits RNA polymerase by sequestering the active center in a catalytically inactive conformation. Here, we show that binding of streptol...
Autores principales: | Zorov, Savva, Yuzenkova, Yulia, Nikiforov, Vadim, Severinov, Konstantin, Zenkin, Nikolay |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957892/ https://www.ncbi.nlm.nih.gov/pubmed/24342645 http://dx.doi.org/10.1128/AAC.02248-13 |
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