C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo

Uncontrolled activation of the complement alternative pathway is associated with complement-mediated renal disease. Factor B and factor D are essential components of this pathway, while factor H (FH) is its major regulator. In complete FH deficiency, uncontrolled C3 activation through the alternativ...

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Detalles Bibliográficos
Autores principales: Ruseva, M M, Takahashi, M, Fujita, T, Pickering, M C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958157/
https://www.ncbi.nlm.nih.gov/pubmed/24279761
http://dx.doi.org/10.1111/cei.12244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958157/
https://www.ncbi.nlm.nih.gov/pubmed/24279761
http://dx.doi.org/10.1111/cei.12244

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