Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a key modulator of the dendritic spine actin cytoskeleton. W...

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Detalles Bibliográficos
Autores principales: Arroyo, Ana I, Camoletto, Paola G, Morando, Laura, Sassoe-Pognetto, Marco, Giustetto, Maurizio, Van Veldhoven, Paul P, Schuchman, Edward H, Ledesma, Maria D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958313/
https://www.ncbi.nlm.nih.gov/pubmed/24448491
http://dx.doi.org/10.1002/emmm.201302649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958313/
https://www.ncbi.nlm.nih.gov/pubmed/24448491
http://dx.doi.org/10.1002/emmm.201302649

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