Cargando…

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of RAS is one of the main conduits through which RAS transmits proliferative signals in normal and cancer cells. Genetic and biochemical studies conducted over the last t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ashton-Beaucage, Dariel, Udell, Christian M., Gendron, Patrick, Sahmi, Malha, Lefrançois, Martin, Baril, Caroline, Guenier, Anne-Sophie, Duchaine, Jean, Lamarre, Daniel, Lemieux, Sébastien, Therrien, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958334/ https://www.ncbi.nlm.nih.gov/pubmed/24643257 http://dx.doi.org/10.1371/journal.pbio.1001809

Ejemplares similares

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila
por: Ashton-Beaucage, Dariel, et al.
Publicado: (2016)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

A comprehensive map of the mTOR signaling network
por: Caron, Etienne, et al.
Publicado: (2010)

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses
por: Baril, Martin, et al.
Publicado: (2013)

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
por: Lemieux, Sebastien, et al.
Publicado: (2017)

CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
por: Serwe, Guillaume, et al.
Publicado: (2023)

Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
por: Siegfried, Zahava, et al.
Publicado: (2013)

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development
por: Shilo, Asaf, et al.
Publicado: (2014)

RAS MAPK inhibitors deregulation in leukemia
por: Pasmant, Eric, et al.
Publicado: (2015)

Splice variants of RAS—translational significance
por: Rásó, Erzsébet
Publicado: (2020)

Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling
por: Umstead, MaKendra, et al.
Publicado: (2017)

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene
por: Gavory, Gwenaëlle, et al.
Publicado: (2021)

Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling
por: Guo, Na, et al.
Publicado: (2016)

The Ras/MAPK Pathway Is Required for Generation of iNKT Cells
por: Hu, Taishan, et al.
Publicado: (2011)

Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
por: Rambur, Amandine, et al.
Publicado: (2020)

Alternative Splicing of MAPKs in the Regulation of Signaling Specificity
por: Maik-Rachline, Galia, et al.
Publicado: (2021)

Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
por: Mittal, Suruchi, et al.
Publicado: (2009)

H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output
por: Rotblat, Barak, et al.
Publicado: (2010)

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA
por: Schmid, Tobias, et al.
Publicado: (2015)

RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action
por: Masliah-Planchon, Julien, et al.
Publicado: (2015)

Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans
por: Sterken, Mark G., et al.
Publicado: (2017)

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
por: Gillies, Taryn E, et al.
Publicado: (2020)

Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers
por: Dillon, Martha, et al.
Publicado: (2021)

Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer
por: Lee, Jennifer J., et al.
Publicado: (2021)

Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities
por: Herman, Jacob A., et al.
Publicado: (2022)

Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel
por: Chatel-Chaix, Laurent, et al.
Publicado: (2010)

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
por: Ji, Jiaojiao, et al.
Publicado: (2019)

Extensive Alternative Splicing of KIR Transcripts
por: Bruijnesteijn, Jesse, et al.
Publicado: (2018)

Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes
por: Maher, Geoffrey J., et al.
Publicado: (2018)

Non‐ossifying fibroma: A RAS‐MAPK driven benign bone neoplasm
por: Bovée, Judith VMG, et al.
Publicado: (2019)

Multiple sources of signal amplification within the B-cell Ras/MAPK pathway
por: Mclaurin, Justin D., et al.
Publicado: (2019)

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
por: Chen, Zhiguo, et al.
Publicado: (2020)

EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions
por: Surve, Sachin, et al.
Publicado: (2021)

Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
por: Tsai, Hong-Chieh, et al.
Publicado: (2021)

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
por: Mlakar, Vid, et al.
Publicado: (2021)

KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders
por: Vendramini, Elena, et al.
Publicado: (2022)

Spotlight on Accessory Proteins: RTK-RAS-MAPK Modulators as New Therapeutic Targets
por: Pudewell, Silke, et al.
Publicado: (2021)

Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
por: Harwood, Stephen J., et al.
Publicado: (2023)

Regulated functional alternative splicing in Drosophila
por: Venables, Julian P., et al.
Publicado: (2012)

Evolution of splicing regulatory networks in Drosophila
por: McManus, C. Joel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_f3acouemnqlirl5hb6ukhnpkni