A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneupl...

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Detalles Bibliográficos
Autores principales: Harrison, Benjamin D., Hashemi, Jordan, Bibi, Maayan, Pulver, Rebecca, Bavli, Danny, Nahmias, Yaakov, Wellington, Melanie, Sapiro, Guillermo, Berman, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958355/
https://www.ncbi.nlm.nih.gov/pubmed/24642609
http://dx.doi.org/10.1371/journal.pbio.1001815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958355/
https://www.ncbi.nlm.nih.gov/pubmed/24642609
http://dx.doi.org/10.1371/journal.pbio.1001815

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