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A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneupl...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958355/ https://www.ncbi.nlm.nih.gov/pubmed/24642609 http://dx.doi.org/10.1371/journal.pbio.1001815 |