Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betulinic Acid Derivatives: Synergistic Effects with Miltefosine

Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries, affecting more than 12 million people. The treatment consists in pentavalent antimony compounds, amphotericin B, pentamidine and miltefosine, among others. However, these current drugs are limited due to their toxicity, d...

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Detalles Bibliográficos
Autores principales: Sousa, Maria C., Varandas, Raquel, Santos, Rita C., Santos-Rosa, Manuel, Alves, Vera, Salvador, Jorge A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958361/
https://www.ncbi.nlm.nih.gov/pubmed/24643019
http://dx.doi.org/10.1371/journal.pone.0089939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958361/
https://www.ncbi.nlm.nih.gov/pubmed/24643019
http://dx.doi.org/10.1371/journal.pone.0089939

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