Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets

The ubiquitin/proteasome system (UPS), a major cellular protein degradation machinery, plays key roles in the regulation of many cell functions. Glucotoxicity mediated by chronic hyperglycaemia is detrimental to the function and survival of pancreatic beta cells. The aim of our study was to determin...

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Detalles Bibliográficos
Autores principales: Broca, Christophe, Varin, Elodie, Armanet, Mathieu, Tourrel-Cuzin, Cécile, Bosco, Domenico, Dalle, Stéphane, Wojtusciszyn, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958412/
https://www.ncbi.nlm.nih.gov/pubmed/24642635
http://dx.doi.org/10.1371/journal.pone.0092066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958412/
https://www.ncbi.nlm.nih.gov/pubmed/24642635
http://dx.doi.org/10.1371/journal.pone.0092066

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