Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT((a))R) with respect to activation of cAMP signaling, β-arrestin recruitment,...

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Detalles Bibliográficos
Autores principales: Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958426/
https://www.ncbi.nlm.nih.gov/pubmed/24643196
http://dx.doi.org/10.1371/journal.pone.0092042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958426/
https://www.ncbi.nlm.nih.gov/pubmed/24643196
http://dx.doi.org/10.1371/journal.pone.0092042

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