Rationalization of Activity Cliffs of a Sulfonamide Inhibitor of DNA Methyltransferases with Induced-Fit Docking

Inhibitors of human DNA methyltransferases (DNMT) are of increasing interest to develop novel epi-drugs for the treatment of cancer and other diseases. As the number of compounds with reported DNMT inhibition is increasing, molecular docking is shedding light to elucidate their mechanism of action a...

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Detalles Bibliográficos
Autores principales: Medina-Franco, José L., Méndez-Lucio, Oscar, Yoo, Jakyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958909/
https://www.ncbi.nlm.nih.gov/pubmed/24566147
http://dx.doi.org/10.3390/ijms15023253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958909/
https://www.ncbi.nlm.nih.gov/pubmed/24566147
http://dx.doi.org/10.3390/ijms15023253

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