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The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases
Damaged and misfolded proteins accumulate during the aging process, impairing cell function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) are hallmarks of age-related neurodegenerative disorders such as Alzheimer’s, Parkinson’s or Huntington’s disease. Damaged pro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bentham Science Publishers
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958958/ https://www.ncbi.nlm.nih.gov/pubmed/24653662 http://dx.doi.org/10.2174/138920291501140306113344 |