HIV-1 persistence in CD4(+) T cells with stem cell-like properties

Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (T(SCM)) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4(+) T cell r...

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Autores principales: Buzon, Maria J., Sun, Hong, Li, Chun, Shaw, Amy, Seiss, Katherine, Ouyang, Zhengyu, Martin-Gayo, Enrique, Leng, Jin, Henrich, Timothy J., Li, Jonathan Z., Pereyra, Florencia, Zurakowski, Ryan, Walker, Bruce D., Rosenberg, Eric S., Yu, Xu G., Lichterfeld, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959167/
https://www.ncbi.nlm.nih.gov/pubmed/24412925
http://dx.doi.org/10.1038/nm.3445
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author Buzon, Maria J.
Sun, Hong
Li, Chun
Shaw, Amy
Seiss, Katherine
Ouyang, Zhengyu
Martin-Gayo, Enrique
Leng, Jin
Henrich, Timothy J.
Li, Jonathan Z.
Pereyra, Florencia
Zurakowski, Ryan
Walker, Bruce D.
Rosenberg, Eric S.
Yu, Xu G.
Lichterfeld, Mathias
author_facet Buzon, Maria J.
Sun, Hong
Li, Chun
Shaw, Amy
Seiss, Katherine
Ouyang, Zhengyu
Martin-Gayo, Enrique
Leng, Jin
Henrich, Timothy J.
Li, Jonathan Z.
Pereyra, Florencia
Zurakowski, Ryan
Walker, Bruce D.
Rosenberg, Eric S.
Yu, Xu G.
Lichterfeld, Mathias
author_sort Buzon, Maria J.
collection PubMed
description Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (T(SCM)) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, phylogenetic studies suggested long-term persistence of viral quasispecies in CD4(+) T(SCM) cells. Thus, HIV-1 may exploit stem cell characteristics of cellular immune memory to promote long-term viral persistence.
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spelling pubmed-39591672014-08-01 HIV-1 persistence in CD4(+) T cells with stem cell-like properties Buzon, Maria J. Sun, Hong Li, Chun Shaw, Amy Seiss, Katherine Ouyang, Zhengyu Martin-Gayo, Enrique Leng, Jin Henrich, Timothy J. Li, Jonathan Z. Pereyra, Florencia Zurakowski, Ryan Walker, Bruce D. Rosenberg, Eric S. Yu, Xu G. Lichterfeld, Mathias Nat Med Article Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (T(SCM)) harbor high per-cell levels of HIV-1 DNA, and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, phylogenetic studies suggested long-term persistence of viral quasispecies in CD4(+) T(SCM) cells. Thus, HIV-1 may exploit stem cell characteristics of cellular immune memory to promote long-term viral persistence. 2014-01-12 2014-02 /pmc/articles/PMC3959167/ /pubmed/24412925 http://dx.doi.org/10.1038/nm.3445 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Buzon, Maria J.
Sun, Hong
Li, Chun
Shaw, Amy
Seiss, Katherine
Ouyang, Zhengyu
Martin-Gayo, Enrique
Leng, Jin
Henrich, Timothy J.
Li, Jonathan Z.
Pereyra, Florencia
Zurakowski, Ryan
Walker, Bruce D.
Rosenberg, Eric S.
Yu, Xu G.
Lichterfeld, Mathias
HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title_full HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title_fullStr HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title_full_unstemmed HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title_short HIV-1 persistence in CD4(+) T cells with stem cell-like properties
title_sort hiv-1 persistence in cd4(+) t cells with stem cell-like properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959167/
https://www.ncbi.nlm.nih.gov/pubmed/24412925
http://dx.doi.org/10.1038/nm.3445
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