CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase

Bacterial RNA polymerase (RNAP) is a validated target for antibacterial drugs. CBR703 series antimicrobials allosterically inhibit transcription by binding to a conserved α helix (β′ bridge helix, BH) that interconnects the two largest RNAP subunits. Here we show that disruption of the BH-β subunit...

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Detalles Bibliográficos
Autores principales: Malinen, Anssi M., NandyMazumdar, Monali, Turtola, Matti, Malmi, Henri, Grocholski, Thadee, Artsimovitch, Irina, Belogurov, Georgiy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959191/
https://www.ncbi.nlm.nih.gov/pubmed/24598909
http://dx.doi.org/10.1038/ncomms4408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959191/
https://www.ncbi.nlm.nih.gov/pubmed/24598909
http://dx.doi.org/10.1038/ncomms4408

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