Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux

BACKGROUND: Nocturnal acid reflux is associated with symptomatic and asymptomatic sleep arousals, leading to fragmented sleep. The frequency and influence of acid reflux in patients with various forms of insomnia has not been reported. The aim of this study was to quantify nocturnal acid and nonacid...

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Autores principales: Herdman, Christine, Marzio, Dina Halegoua-De, Shah, Paurush, Denuna-Rivera, Susie, Doghramji, Karl, Cohen, Sidney, DiMarino, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959439/
https://www.ncbi.nlm.nih.gov/pubmed/24714269
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author Herdman, Christine
Marzio, Dina Halegoua-De
Shah, Paurush
Denuna-Rivera, Susie
Doghramji, Karl
Cohen, Sidney
DiMarino, Anthony J.
author_facet Herdman, Christine
Marzio, Dina Halegoua-De
Shah, Paurush
Denuna-Rivera, Susie
Doghramji, Karl
Cohen, Sidney
DiMarino, Anthony J.
author_sort Herdman, Christine
collection PubMed
description BACKGROUND: Nocturnal acid reflux is associated with symptomatic and asymptomatic sleep arousals, leading to fragmented sleep. The frequency and influence of acid reflux in patients with various forms of insomnia has not been reported. The aim of this study was to quantify nocturnal acid and nonacid reflux in patients with primary sleep disorders as previously diagnosed by polysomnography. METHODS: Thirty one subjects were studied: (A) 9 subjects with a polysomnographically diagnosed sleep disorder (1 with restless legs syndrome, 4 with narcolepsy, 4 with periodic limb movement disorder); (B) 12 subjects with primary insomnia (PI) and unrevealing polysomnography; and (C) 10 controls without disturbed sleep. All subjects underwent a physical examination and 24 h transnasal pH and impedance monitoring to detect acid and non-acid reflux. RESULTS: The 21 subjects with fragmented sleep due to a primary sleep disorder had significantly more recumbent acid exposure (>1.2% of time) as compared with control subjects (33% versus 0%). When fragmented sleep subjects were divided into two groups, 17% of PI subjects and 55% of subjects with a diagnosed sleep disorder had significant recumbent acid exposure (P=0.009). Likewise, the median recumbent nonacid events were increased in the sleep disordered group (P=0.011). CONCLUSIONS: This study indicates that patients with primary sleep disorders have prominent nocturnal acid reflux without symptoms of daytime acid reflux. Acid reflux is most prominent in patients with polysomnographic findings of disturbed sleep as compared to patients with PI; while non acid reflux is increased minimally in these patients.
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spelling pubmed-39594392014-04-07 Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux Herdman, Christine Marzio, Dina Halegoua-De Shah, Paurush Denuna-Rivera, Susie Doghramji, Karl Cohen, Sidney DiMarino, Anthony J. Ann Gastroenterol Original Article BACKGROUND: Nocturnal acid reflux is associated with symptomatic and asymptomatic sleep arousals, leading to fragmented sleep. The frequency and influence of acid reflux in patients with various forms of insomnia has not been reported. The aim of this study was to quantify nocturnal acid and nonacid reflux in patients with primary sleep disorders as previously diagnosed by polysomnography. METHODS: Thirty one subjects were studied: (A) 9 subjects with a polysomnographically diagnosed sleep disorder (1 with restless legs syndrome, 4 with narcolepsy, 4 with periodic limb movement disorder); (B) 12 subjects with primary insomnia (PI) and unrevealing polysomnography; and (C) 10 controls without disturbed sleep. All subjects underwent a physical examination and 24 h transnasal pH and impedance monitoring to detect acid and non-acid reflux. RESULTS: The 21 subjects with fragmented sleep due to a primary sleep disorder had significantly more recumbent acid exposure (>1.2% of time) as compared with control subjects (33% versus 0%). When fragmented sleep subjects were divided into two groups, 17% of PI subjects and 55% of subjects with a diagnosed sleep disorder had significant recumbent acid exposure (P=0.009). Likewise, the median recumbent nonacid events were increased in the sleep disordered group (P=0.011). CONCLUSIONS: This study indicates that patients with primary sleep disorders have prominent nocturnal acid reflux without symptoms of daytime acid reflux. Acid reflux is most prominent in patients with polysomnographic findings of disturbed sleep as compared to patients with PI; while non acid reflux is increased minimally in these patients. Hellenic Society of Gastroenterology 2013 /pmc/articles/PMC3959439/ /pubmed/24714269 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Herdman, Christine
Marzio, Dina Halegoua-De
Shah, Paurush
Denuna-Rivera, Susie
Doghramji, Karl
Cohen, Sidney
DiMarino, Anthony J.
Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title_full Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title_fullStr Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title_full_unstemmed Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title_short Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
title_sort sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959439/
https://www.ncbi.nlm.nih.gov/pubmed/24714269
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