IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

BACKGROUND: Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin‐6 (IL‐6) secretion, we e...

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Detalles Bibliográficos
Autores principales: Ju, Xiaoxi, Ijaz, Talha, Sun, Hong, LeJeune, Wanda, Vargas, Gracie, Shilagard, Tuya, Recinos, Adrian, Milewicz, Dianna M., Brasier, Allan R., Tilton, Ronald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959679/
https://www.ncbi.nlm.nih.gov/pubmed/24449804
http://dx.doi.org/10.1161/JAHA.113.000476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959679/
https://www.ncbi.nlm.nih.gov/pubmed/24449804
http://dx.doi.org/10.1161/JAHA.113.000476

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