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Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design
[Image: see text] Anfinsen’s principle asserts that all information required to specify the structure of a protein is encoded in its amino acid sequence. However, during protein synthesis by the ribosome, the N-terminus of the nascent chain can begin to fold before the C-terminus is available. We te...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959793/ https://www.ncbi.nlm.nih.gov/pubmed/24392935 http://dx.doi.org/10.1021/ja411302m |