High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27(Kip1) Transcriptional Inhibitor

p27(Kip1) is a cell cycle inhibitor that prevents cyclin dependent kinase (CDK)/cyclin complexes from phosphorylating their targets. p27(Kip1) is a known tumor suppressor, as the germline loss of p27(Kip1) results in sporadic pituitary formation in aged rodents, and its presence in human cancers is...

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Detalles Bibliográficos
Autores principales: Walters, Brandon J., Lin, Wenwei, Diao, Shiyong, Brimble, Mark, Iconaru, Luigi I., Dearman, Jennifer, Goktug, Asli, Chen, Taosheng, Zuo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960108/
https://www.ncbi.nlm.nih.gov/pubmed/24646893
http://dx.doi.org/10.1371/journal.pone.0091173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960108/
https://www.ncbi.nlm.nih.gov/pubmed/24646893
http://dx.doi.org/10.1371/journal.pone.0091173

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