Cargando…

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation

TSC2 (Tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. TSC2 protein complexes with TSC1 and blocks the ability of the Rheb (Ras homolog enriched in brain) GTPase t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Munkley, Jennifer, Rajan, Prabhakar, Laferty, Nicholas P., Dalgliesh, Caroline, Jackson, Robert M., Robson, Craig N., Leung, Hing Y., Elliott, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960195/ https://www.ncbi.nlm.nih.gov/pubmed/24318044

Ejemplares similares

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells
por: Munkley, Jennifer, et al.
Publicado: (2015)

Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome
por: Rajan, Prabhakar, et al.
Publicado: (2011)

Androgen-dependent alternative mRNA isoform expression in prostate cancer cells
por: Munkley, Jennifer, et al.
Publicado: (2018)

Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability()
por: Munkley, Jennifer, et al.
Publicado: (2016)

The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
por: Stockley, Jacqueline, et al.
Publicado: (2015)

The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells
por: Munkley, Jennifer, et al.
Publicado: (2015)

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
por: Munkley, Jennifer, et al.
Publicado: (2017)

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies
por: Rajan, Prabhakar, et al.
Publicado: (2009)

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
por: Munkley, Jennifer, et al.
Publicado: (2015)

RNA splicing and splicing regulator changes in prostate cancer pathology
por: Munkley, Jennifer, et al.
Publicado: (2017)

Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts
por: Goncharova, Elena A., et al.
Publicado: (2014)

Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer
por: Advani, Rahul, et al.
Publicado: (2023)

An expanded role of the tumor suppressor TSC1 in T cell tolerance
por: Zhong, Xiao-Ping
Publicado: (2012)

Correction: Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts
Publicado: (2015)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth
por: Gluderer, Silvia, et al.
Publicado: (2008)

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2
por: Lin, Hui-Ping, et al.
Publicado: (2015)

The von Hippel–Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform
por: Chesnel, F, et al.
Publicado: (2015)

Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation
por: Zoch, Ansgar, et al.
Publicado: (2015)

OR05-06 The Androgen Receptor Is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer
por: Hickey, Theresa E, et al.
Publicado: (2020)

ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer
por: Melekhova, Anna, et al.
Publicado: (2021)

Mutational analysis of TSC1 and TSC2 in Danish patients with tuberous sclerosis complex
por: Rosengren, Thomas, et al.
Publicado: (2020)

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
por: Li, Yi, et al.
Publicado: (2018)

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
por: Munkley, Jennifer, et al.
Publicado: (2019)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
por: Braun, Clarissa, et al.
Publicado: (2021)

Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2(−)/(−) Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM
por: Lesma, Elena, et al.
Publicado: (2008)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

Targeted Next Generation Sequencing reveals previously unidentified TSC1 and TSC2 mutations
por: Nellist, Mark, et al.
Publicado: (2015)

Stochastic Model of Tsc1 Lesions in Mouse Brain
por: Prabhakar, Shilpa, et al.
Publicado: (2013)

Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas
por: Parry, L, et al.
Publicado: (2001)

Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2019)

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients
por: Jiangyi, Wang, et al.
Publicado: (2020)

Recombinant Tumor Suppressor TSC1 Differentially Interacts with Escherichia coli DnaK and Human HSP70
por: Natarajan, Nalini, et al.
Publicado: (2020)

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients
por: Woodford, Mark R, et al.
Publicado: (2017)

Molecular analysis of TSC1 and TSC2 genes and phenotypic correlations in Brazilian families with tuberous sclerosis
por: Rosset, Clévia, et al.
Publicado: (2017)

Androgen receptor isoforms expression in benign prostatic hyperplasia and primary prostate cancer
por: Hillebrand, Ana Caroline, et al.
Publicado: (2018)

Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2020)

Correction: Stochastic Model of Tsc1 Lesions in Mouse Brain
por: Prabhakar, Shilpa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_309ndbn0qdqojrvc62i37e25df