Diffuse Glomerular Nodular Lesions in Diabetic Pigs Carrying a Dominant-Negative Mutant Hepatocyte Nuclear Factor 1-Alpha, an Inheritant Diabetic Gene in Humans

Glomerular nodular lesions, known as Kimmelstiel-Wilson nodules, are a pathological hallmark of progressive human diabetic nephropathy. We have induced severe diabetes in pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (HNF1α) P291fsinsC, a maturity-onset diabetes of the y...

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Detalles Bibliográficos
Autores principales: Hara, Satoshi, Umeyama, Kazuhiro, Yokoo, Takashi, Nagashima, Hiroshi, Nagata, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960229/
https://www.ncbi.nlm.nih.gov/pubmed/24647409
http://dx.doi.org/10.1371/journal.pone.0092219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960229/
https://www.ncbi.nlm.nih.gov/pubmed/24647409
http://dx.doi.org/10.1371/journal.pone.0092219

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