Development of a Human Breast-Cancer Derived Cell Line Stably Expressing a Bioluminescence Resonance Energy Transfer (BRET)-Based Phosphatidyl Inositol-3 Phosphate (PIP(3)) Biosensor

Stimulation of tyrosine kinase receptors initiates a signaling cascade that activates PI3K. Activated PI3K uses PIP(2) to generate PIP(3), which recruit Akt to the plasma membrane through its pleckstrin homology (PH) domain, permitting its activation by PDKs. Activated Akt controls important biologi...

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Detalles Bibliográficos
Autores principales: Kuo, Mei-Shiue, Auriau, Johanna, Pierre-Eugène, Cécile, Issad, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960261/
https://www.ncbi.nlm.nih.gov/pubmed/24647478
http://dx.doi.org/10.1371/journal.pone.0092737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960261/
https://www.ncbi.nlm.nih.gov/pubmed/24647478
http://dx.doi.org/10.1371/journal.pone.0092737

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