Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

Tumor suppressor p53 is frequently mutated in tumors. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 often accumulates at high levels in tumors, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Tongsen, Wang, Jiabei, Zhao, Yuhan, Zhang, Cen, Lin, Meihua, Wang, Xiaowen, Yu, Haiyang, Liu, Lianxin, Feng, Zhaohui, Hu, Wenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960723/
https://www.ncbi.nlm.nih.gov/pubmed/24356649
http://dx.doi.org/10.1038/ncomms3996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960723/
https://www.ncbi.nlm.nih.gov/pubmed/24356649
http://dx.doi.org/10.1038/ncomms3996

Ejemplares similares