Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes

Casitas B-lineage lymphoma-b (Cbl-b) is a ubiquitin ligase (E3) that modulates signaling by tagging molecules for degradation. It is a complex protein with multiple domains and binding partners that are not involved in ubiquitinating substrates. Herein, we demonstrate that Cbl-b, but not c-Cbl, is r...

Descripción completa

Detalles Bibliográficos
Autores principales: Veselits, Margaret, Tanaka, Azusa, Lipkowitz, Stanley, O'Neill, Shannon, Sciammas, Roger, Finnegan, Alison, Zhang, Jian, Clark, Marcus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961229/
https://www.ncbi.nlm.nih.gov/pubmed/24651487
http://dx.doi.org/10.1371/journal.pone.0089792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961229/
https://www.ncbi.nlm.nih.gov/pubmed/24651487
http://dx.doi.org/10.1371/journal.pone.0089792

Ejemplares similares