High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity

Here, we demonstrate how array-based label-free biosensors can be applied to the multiplexed interaction analysis of large panels of analyte/ligand pairs, such as the epitope binning of monoclonal antibodies (mAbs). In this application, the larger the number of mAbs that are analyzed for cross-block...

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Detalles Bibliográficos
Autores principales: Abdiche, Yasmina Noubia, Miles, Adam, Eckman, Josh, Foletti, Davide, Van Blarcom, Thomas J., Yeung, Yik Andy, Pons, Jaume, Rajpal, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961344/
https://www.ncbi.nlm.nih.gov/pubmed/24651868
http://dx.doi.org/10.1371/journal.pone.0092451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961344/
https://www.ncbi.nlm.nih.gov/pubmed/24651868
http://dx.doi.org/10.1371/journal.pone.0092451

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