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Characterisation of Genetic Variation in ST8SIA2 and Its Interaction Region in NCAM1 in Patients with Bipolar Disorder

Alpha-2,8-sialyltransferase 2 (ST8SIA2) is an enzyme responsible for the transfer of polysialic acid (PSA) to glycoproteins, principally the neuronal cell adhesion molecule (NCAM1), and is involved in neuronal plasticity. Variants within ST8SIA2 have previously shown association with bipolar disorde...

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Detalles Bibliográficos
Autores principales: Shaw, Alex D., Tiwari, Yash, Kaplan, Warren, Heath, Anna, Mitchell, Philip B., Schofield, Peter R., Fullerton, Janice M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961385/
https://www.ncbi.nlm.nih.gov/pubmed/24651862
http://dx.doi.org/10.1371/journal.pone.0092556