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Integer Programming-Based Method for Designing Synthetic Metabolic Networks by Minimum Reaction Insertion in a Boolean Model

In this paper, we consider the Minimum Reaction Insertion (MRI) problem for finding the minimum number of additional reactions from a reference metabolic network to a host metabolic network so that a target compound becomes producible in the revised host metabolic network in a Boolean model. Althoug...

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Detalles Bibliográficos
Autores principales: Lu, Wei, Tamura, Takeyuki, Song, Jiangning, Akutsu, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961429/
https://www.ncbi.nlm.nih.gov/pubmed/24651476
http://dx.doi.org/10.1371/journal.pone.0092637