A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy

Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination...

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Detalles Bibliográficos
Autores principales: Cherfils-Vicini, Julien, Zizza, Pasquale, Gilson, Eric, Biroccio, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961481/
https://www.ncbi.nlm.nih.gov/pubmed/24701373
http://dx.doi.org/10.4161/onci.27358
Descripción
Sumario:Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination of aged, damaged, and neoplastic cells by the immune system, opening the way to new therapeutic options against cancer.

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