Genetic variants of IgG1 antibodies and FcγRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells

Antibody-dependent, cell-mediated cytotoxicity (ADCC) is one of the major mechanisms underlying the clinical efficacy of anticancer monoclonal antibodies (mAbs), such as the mucin 1 (MUC1)-targeting molecule HuHMFG1. IgG antibodies trigger ADCC upon interaction with Fcγ receptors (FcγRs) expressed o...

Descripción completa

Detalles Bibliográficos
Autores principales: Pandey, Janardan P, Namboodiri, Aryan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961482/
https://www.ncbi.nlm.nih.gov/pubmed/24701371
http://dx.doi.org/10.4161/onci.27317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961482/
https://www.ncbi.nlm.nih.gov/pubmed/24701371
http://dx.doi.org/10.4161/onci.27317

Ejemplares similares