Cargando…

Genetic variants of IgG1 antibodies and FcγRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells

Antibody-dependent, cell-mediated cytotoxicity (ADCC) is one of the major mechanisms underlying the clinical efficacy of anticancer monoclonal antibodies (mAbs), such as the mucin 1 (MUC1)-targeting molecule HuHMFG1. IgG antibodies trigger ADCC upon interaction with Fcγ receptors (FcγRs) expressed o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandey, Janardan P, Namboodiri, Aryan M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961482/ https://www.ncbi.nlm.nih.gov/pubmed/24701371 http://dx.doi.org/10.4161/onci.27317

Ejemplares similares

Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding
por: Lu, Xiaojun, et al.
Publicado: (2020)

Role of N-Glycosylation in FcγRIIIa interaction with IgG
por: Van Coillie, Julie, et al.
Publicado: (2022)

Biophysical Characterization of the Contribution of the Fab Region to the IgG-FcγRIIIa Interaction
por: Kosuge, Hirofumi, et al.
Publicado: (2022)

Cross-species higher sensitivities of FcγRIIIA/FcγRIV to afucosylated IgG for enhanced ADCC
por: Mao, Changchuin, et al.
Publicado: (2021)

The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation
por: Shibata-Koyama, Mami, et al.
Publicado: (2009)

Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors
por: Isoda, Yuya, et al.
Publicado: (2015)

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages
por: Maemura, Tadashi, et al.
Publicado: (2021)

Enhancing the therapeutic activity of hyperimmune IgG against chikungunya virus using FcγRIIIa affinity chromatography
por: Fox, Julie M., et al.
Publicado: (2023)

An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa(V158) Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages
por: Kang, Tae Hyun, et al.
Publicado: (2019)

Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children
por: Nasr, Amre, et al.
Publicado: (2021)

Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand
por: Kosuge, Hirofumi, et al.
Publicado: (2020)

Chronic HIV-1 Infection Alters the Cellular Distribution of FcγRIIIa and the Functional Consequence of the FcγRIIIa-F158V Variant
por: Phaahla, Ntando G., et al.
Publicado: (2019)

Specific location of galactosylation in an afucosylated antiviral monoclonal antibody affects its FcγRIIIA binding affinity
por: Hatfield, Grayson, et al.
Publicado: (2022)

Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography
por: Hiranyakorn, Methanee, et al.
Publicado: (2023)

Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor FcγRIIB
por: Petkova, Stefka B., et al.
Publicado: (2006)

HA Antibody-Mediated FcγRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids
por: Cox, Freek, et al.
Publicado: (2016)

FcγRIIa and FcγRIIIa genes polymorphism in Egyptian children with primary immune thrombocytopenia
por: Zakaria, Marwa, et al.
Publicado: (2023)

High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19
por: Vietzen, Hannes, et al.
Publicado: (2022)

FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV
por: Talathi, Sneha Pramod, et al.
Publicado: (2019)

Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index
por: Karimifar, Mansoor, et al.
Publicado: (2021)

IgG3 constant region GM (γ marker) allotypes could influence the neutralizing potency of anti–SARS-CoV-2 monoclonal antibodies
por: Pandey, Janardan P.
Publicado: (2022)

The impact of FcγRIIa and FcγRIIIa gene polymorphisms on responses to RCHOP chemotherapy in diffuse large B-cell lymphoma patients
por: ROŽMAN, SAMO, et al.
Publicado: (2016)

Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions
por: Capuano, Cristina, et al.
Publicado: (2023)

Correction to: Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index
por: Karimifar, Mansoor, et al.
Publicado: (2022)

IgG Fc engineering to modulate antibody effector functions
por: Wang, Xinhua, et al.
Publicado: (2017)

The role of IgG Fc receptors in antibody-dependent enhancement
por: Bournazos, Stylianos, et al.
Publicado: (2020)

The Binding of Human IgG to Minipig FcγRs – Implications for Preclinical Assessment of Therapeutic Antibodies
por: Egli, Jerome, et al.
Publicado: (2019)

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production
por: Capuano, Cristina, et al.
Publicado: (2017)

Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy
por: Zhu, Wen, et al.
Publicado: (2023)

Signal transduction by the CD2 antigen in T cells and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16)
Publicado: (1991)

IgG and Fcγ Receptors in Intestinal Immunity and Inflammation
por: Castro-Dopico, Tomas, et al.
Publicado: (2019)

Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients
por: Thibault, Gilles, et al.
Publicado: (2021)

The role of Fc–FcγR interactions in IgG-mediated microbial neutralization
por: Bournazos, Stylianos, et al.
Publicado: (2015)

Oligomannose N-Glycans 3D Architecture and Its Response to the FcγRIIIa Structural Landscape
por: Fogarty, Carl A, et al.
Publicado: (2021)

Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA
por: Cottignies-Calamarte, Andréa, et al.
Publicado: (2023)

Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities
por: Kurogochi, Masaki, et al.
Publicado: (2015)

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies
por: Golay, Josée, et al.
Publicado: (2022)

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis
por: Allhorn, Maria, et al.
Publicado: (2008)

FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
por: Larsson, Per Flodbring, et al.
Publicado: (2022)

Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
por: Naluyima, Prossy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_52j3sih1e8jnf8bm5o12jh444d