Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes

Plakophilin-1 (PKP-1) is an armadillo family protein critical for desmosomal adhesion and epidermal integrity. In the autoimmune skin blistering disease pemphigus vulgaris (PV), autoantibodies (IgG) target the desmosomal cadherin desmoglein 3 (Dsg3) and compromise keratinocyte cell-cell adhesion. He...

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Detalles Bibliográficos
Autores principales: Tucker, Dana K., Stahley, Sara N., Kowalczyk, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961504/
https://www.ncbi.nlm.nih.gov/pubmed/24056861
http://dx.doi.org/10.1038/jid.2013.401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961504/
https://www.ncbi.nlm.nih.gov/pubmed/24056861
http://dx.doi.org/10.1038/jid.2013.401

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