Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

Nonribosomal peptide synthetases (NRPSs) are versatile engines of bioactive natural product biosynthesis that function according to the multiple carrier thiotemplate mechanism. C-terminal thioesterase (TE) domains of these giant modular proteins typically catalyze product release by hydrolysis or ma...

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Detalles Bibliográficos
Autores principales: Gaudelli, Nicole M., Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961552/
https://www.ncbi.nlm.nih.gov/pubmed/24531841
http://dx.doi.org/10.1038/nchembio.1456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961552/
https://www.ncbi.nlm.nih.gov/pubmed/24531841
http://dx.doi.org/10.1038/nchembio.1456

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