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Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis
Nonribosomal peptide synthetases (NRPSs) are versatile engines of bioactive natural product biosynthesis that function according to the multiple carrier thiotemplate mechanism. C-terminal thioesterase (TE) domains of these giant modular proteins typically catalyze product release by hydrolysis or ma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961552/ https://www.ncbi.nlm.nih.gov/pubmed/24531841 http://dx.doi.org/10.1038/nchembio.1456 |