Computational tools for rational protein engineering of aldolases

In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This a...

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Detalles Bibliográficos
Autores principales: Widmann, Michael, Pleiss, Jürgen, Samland, Anne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2012
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962226/
https://www.ncbi.nlm.nih.gov/pubmed/24688657
http://dx.doi.org/10.5936/csbj.201209016
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author Widmann, Michael
Pleiss, Jürgen
Samland, Anne K.
author_facet Widmann, Michael
Pleiss, Jürgen
Samland, Anne K.
author_sort Widmann, Michael
collection PubMed
description In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.
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spelling pubmed-39622262014-03-31 Computational tools for rational protein engineering of aldolases Widmann, Michael Pleiss, Jürgen Samland, Anne K. Comput Struct Biotechnol J Mini Review In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review. Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2012-11-13 /pmc/articles/PMC3962226/ /pubmed/24688657 http://dx.doi.org/10.5936/csbj.201209016 Text en © Widmann et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited.
spellingShingle Mini Review
Widmann, Michael
Pleiss, Jürgen
Samland, Anne K.
Computational tools for rational protein engineering of aldolases
title Computational tools for rational protein engineering of aldolases
title_full Computational tools for rational protein engineering of aldolases
title_fullStr Computational tools for rational protein engineering of aldolases
title_full_unstemmed Computational tools for rational protein engineering of aldolases
title_short Computational tools for rational protein engineering of aldolases
title_sort computational tools for rational protein engineering of aldolases
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962226/
https://www.ncbi.nlm.nih.gov/pubmed/24688657
http://dx.doi.org/10.5936/csbj.201209016
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