Centrosome-Kinase Fusions Promote Oncogenic Signaling and Disrupt Centrosome Function in Myeloproliferative Neoplasms

Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling. The function of centrosome proteins in these fusion...

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Detalles Bibliográficos
Autores principales: Lee, Joanna Y., Hong, Wan-Jen, Majeti, Ravindra, Stearns, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962438/
https://www.ncbi.nlm.nih.gov/pubmed/24658090
http://dx.doi.org/10.1371/journal.pone.0092641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962438/
https://www.ncbi.nlm.nih.gov/pubmed/24658090
http://dx.doi.org/10.1371/journal.pone.0092641

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