3-Methylcholanthrene, an AhR Agonist, Caused Cell-Cycle Arrest by Histone Deacetylation through a RhoA-Dependent Recruitment of HDAC1 and pRb2 to E2F1 Complex

We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase, Cdk2. We further investigated the molecular me...

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Detalles Bibliográficos
Autores principales: Chang, Chih-Cheng, Sue, Yuh-Mou, Yang, Nian-Jie, Lee, Yi-Hsuan, Juan, Shu-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962457/
https://www.ncbi.nlm.nih.gov/pubmed/24658119
http://dx.doi.org/10.1371/journal.pone.0092793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962457/
https://www.ncbi.nlm.nih.gov/pubmed/24658119
http://dx.doi.org/10.1371/journal.pone.0092793

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