Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C

Mammalian cathepsin C is primarily responsible for the removal of N-terminal dipeptides and activation of several serine proteases in inflammatory or immune cells, while its malarial parasite ortholog dipeptidyl aminopeptidase 1 plays a crucial role in catabolizing the hemoglobin of its host erythro...

Descripción completa

Detalles Bibliográficos
Autores principales: Poreba, Marcin, Mihelic, Marko, Krai, Priscilla, Rajkovic, Jelena, Krezel, Artur, Pawelczak, Malgorzata, Klemba, Michael, Turk, Dusan, Turk, Boris, Latajka, Rafal, Drag, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962583/
https://www.ncbi.nlm.nih.gov/pubmed/24381006
http://dx.doi.org/10.1007/s00726-013-1654-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962583/
https://www.ncbi.nlm.nih.gov/pubmed/24381006
http://dx.doi.org/10.1007/s00726-013-1654-2

Ejemplares similares