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Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C
Mammalian cathepsin C is primarily responsible for the removal of N-terminal dipeptides and activation of several serine proteases in inflammatory or immune cells, while its malarial parasite ortholog dipeptidyl aminopeptidase 1 plays a crucial role in catabolizing the hemoglobin of its host erythro...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962583/ https://www.ncbi.nlm.nih.gov/pubmed/24381006 http://dx.doi.org/10.1007/s00726-013-1654-2 |