A Functional Interaction between Hippo-YAP Signaling and FoxO1 Mediates the Oxidative Stress Response

The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that YAP, the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival. YAP a...

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Detalles Bibliográficos
Autores principales: Shao, Dan, Zhai, Peiyong, Del Re, Dominic P., Sciarretta, Sebastiano, Yabuta, Norikazu, Nojima, Hiroshi, Lim, Dae-Sik, Pan, Duojia, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962829/
https://www.ncbi.nlm.nih.gov/pubmed/24525530
http://dx.doi.org/10.1038/ncomms4315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962829/
https://www.ncbi.nlm.nih.gov/pubmed/24525530
http://dx.doi.org/10.1038/ncomms4315

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