Induction of nuclear translocation of mutant cytoplasmic p53 by geranylgeranoic acid in a human hepatoma cell line

Mutant p53 proteins in human hepatoma cell lines such as HuH-7 (Y220C) and PLC/PRF/5 (R249S) accumulate in the cytoplasm, and lose their transcriptional function. Geranylgeranoic acid (GGA) is a naturally occurring acyclic diterpenoid that induces cell death in both cell lines, but not in HepG2 cell...

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Detalles Bibliográficos
Autores principales: Iwao, Chieko, Shidoji, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963086/
https://www.ncbi.nlm.nih.gov/pubmed/24658405
http://dx.doi.org/10.1038/srep04419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963086/
https://www.ncbi.nlm.nih.gov/pubmed/24658405
http://dx.doi.org/10.1038/srep04419

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