Molecular and Population Analysis of Natural Selection on the Human Haptoglobin Duplication

Haptoglobin binds free haemoglobin that prevents oxidative damage produced by haemolysis. There is a copy number variant (CNV) in the haptoglobin gene (HP) consisting of two alleles, Hp1 (no duplication), and Hp2 (1.7kb duplication involving two exons). The spread of the Hp2 allele is believed to ha...

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Detalles Bibliográficos
Autores principales: Rodriguez, Santiago, Williams, Dylan M, Guthrie, Philip AI, McArdle, Wendy L, Smith, George Davey, Evans, David M, Gaunt, Tom R, Day, Ian NM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963445/
https://www.ncbi.nlm.nih.gov/pubmed/22607059
http://dx.doi.org/10.1111/j.1469-1809.2012.00716.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963445/
https://www.ncbi.nlm.nih.gov/pubmed/22607059
http://dx.doi.org/10.1111/j.1469-1809.2012.00716.x

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