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Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium

BACKGROUND: A defining characteristic of the human intestinal epithelium is that it is the most rapidly renewing tissue in the body. However, the processes underlying tissue renewal and the mechanisms that govern their coordination have proved difficult to study in the human gut. OBJECTIVE: To inves...

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Detalles Bibliográficos
Autores principales: Reynolds, Amy, Wharton, Natalia, Parris, Alyson, Mitchell, Esther, Sobolewski, Anastasia, Kam, Christy, Bigwood, Loren, El Hadi, Ahmed, Münsterberg, Andrea, Lewis, Michael, Speakman, Christopher, Stebbings, William, Wharton, Richard, Sargen, Kevin, Tighe, Richard, Jamieson, Crawford, Hernon, James, Kapur, Sandeep, Oue, Naohide, Yasui, Wataru, Williams, Mark R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963552/
https://www.ncbi.nlm.nih.gov/pubmed/23831735
http://dx.doi.org/10.1136/gutjnl-2012-304067