Interference of Co-Amplified Nuclear Mitochondrial DNA Sequences on the Determination of Human mtDNA Heteroplasmy by Using the SURVEYOR Nuclease and the WAVE HS System

High-sensitivity and high-throughput mutation detection techniques are useful for screening the homoplasmy or heteroplasmy status of mitochondrial DNA (mtDNA), but might be susceptible to interference from nuclear mitochondrial DNA sequences (NUMTs) co-amplified during polymerase chain reaction (PCR...

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Detalles Bibliográficos
Autores principales: Yen, Hsiu-Chuan, Li, Shiue-Li, Hsu, Wei-Chien, Tang, Petrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963942/
https://www.ncbi.nlm.nih.gov/pubmed/24664244
http://dx.doi.org/10.1371/journal.pone.0092817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963942/
https://www.ncbi.nlm.nih.gov/pubmed/24664244
http://dx.doi.org/10.1371/journal.pone.0092817

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