Cargando…

Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our method aims at extracting such constraints from rapidly accu...

Descripción completa

Detalles Bibliográficos
Autores principales: Baldassi, Carlo, Zamparo, Marco, Feinauer, Christoph, Procaccini, Andrea, Zecchina, Riccardo, Weigt, Martin, Pagnani, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963956/
https://www.ncbi.nlm.nih.gov/pubmed/24663061
http://dx.doi.org/10.1371/journal.pone.0092721