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Escalation with Overdose Control Using Time to Toxicity for Cancer Phase I Clinical Trials
Escalation with overdose control (EWOC) is a Bayesian adaptive phase I clinical trial design that produces consistent sequences of doses while controlling the probability that patients are overdosed. However, this design does not take explicitly into account the time it takes for a patient to exhibi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963973/ https://www.ncbi.nlm.nih.gov/pubmed/24663812 http://dx.doi.org/10.1371/journal.pone.0093070 |