Direct T Cell Activation via CD40 Ligand Generates High Avidity CD8(+) T Cells Capable of Breaking Immunological Tolerance for the Control of Tumors

CD40 and CD40 ligand (CD40L) are costimulatory molecules that play a pivotal role in the proinflammatory immune response. Primarily expressed by activated CD4(+) T cells, CD40L binds to CD40 on antigen presenting cells (APCs), thereby inducing APC activation. APCs, in turn, prime cytotoxic T lymphoc...

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Detalles Bibliográficos
Autores principales: Soong, Ruey-Shyang, Song, Liwen, Trieu, Janson, Lee, Sung Yong, He, Liangmei, Tsai, Ya-Chea, Wu, T.-C., Hung, Chien-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963987/
https://www.ncbi.nlm.nih.gov/pubmed/24664420
http://dx.doi.org/10.1371/journal.pone.0093162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963987/
https://www.ncbi.nlm.nih.gov/pubmed/24664420
http://dx.doi.org/10.1371/journal.pone.0093162

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