Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites

Gain-of-function mutant p53 is thought to induce gene expression in part by binding transcription factors bound to promoters for genes that mediate oncogenesis. We investigated the mechanism of mutant p53 binding by mapping the human genomic binding sites for p53 R273H using ChIP-Seq and showed them...

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Detalles Bibliográficos
Autores principales: Vaughan, Catherine A., Deb, Swati P., Deb, Sumitra, Windle, Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964217/
https://www.ncbi.nlm.nih.gov/pubmed/24481480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964217/
https://www.ncbi.nlm.nih.gov/pubmed/24481480

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