Nanomechanics of β-rich proteins related to neuronal disorders studied by AFM, all-atom and coarse-grained MD methods

Computer simulations of protein unfolding substantially help to interpret force-extension curves measured in single-molecule atomic force microscope (AFM) experiments. Standard all-atom (AA) molecular dynamics simulations (MD) give a good qualitative mechanical unfolding picture but predict values t...

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Detalles Bibliográficos
Autores principales: Mikulska, Karolina, Strzelecki, Janusz, Nowak, Wiesław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964301/
https://www.ncbi.nlm.nih.gov/pubmed/24562857
http://dx.doi.org/10.1007/s00894-014-2144-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964301/
https://www.ncbi.nlm.nih.gov/pubmed/24562857
http://dx.doi.org/10.1007/s00894-014-2144-5

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