Synthetic mammalian transgene negative autoregulation

Biological networks contain overrepresented small-scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative-feedback loop, where a gene product represses its own transcription. Here, using synthetic circuits stably integrated in human kidney cells, we st...

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Detalles Bibliográficos
Autores principales: Shimoga, Vinay, White, Jacob T, Li, Yi, Sontag, Eduardo, Bleris, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964311/
https://www.ncbi.nlm.nih.gov/pubmed/23736683
http://dx.doi.org/10.1038/msb.2013.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964311/
https://www.ncbi.nlm.nih.gov/pubmed/23736683
http://dx.doi.org/10.1038/msb.2013.27

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