Cargando…

P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells

Objectives. The mechanism underlying the regulation of glucolipotoxicity-induced apoptosis by MAPKs was examined in INS-1 cells. Methods. The rat insulinoma cell line INS-1 was cotreated with glucose (30 mM) and palmitic acid (0.2 mM) (GLU+PA). Apoptosis was assessed by cell morphology and detection...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Lingli, Cai, Xiaoling, Han, Xueyao, Ji, Linong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964802/ https://www.ncbi.nlm.nih.gov/pubmed/24734256 http://dx.doi.org/10.1155/2014/834528

Ejemplares similares

The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition
por: Kwon, Min Jeong, et al.
Publicado: (2011)

Yunvjian-Medicated Serum Protects INS-1 Cells against Glucolipotoxicity-Induced Apoptosis through Autophagic Flux Modulation
por: He, Caigu, et al.
Publicado: (2020)

Glucolipotoxicity Impairs Ceramide Flow from the Endoplasmic Reticulum to the Golgi Apparatus in INS-1 β-Cells
por: Gjoni, Enida, et al.
Publicado: (2014)

Glucolipotoxicity in Pancreatic β-Cells
por: Kim, Ji-Won, et al.
Publicado: (2011)

Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population
por: Cai, Xiaoling, et al.
Publicado: (2017)

Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions
por: Kwon, Min Jeong, et al.
Publicado: (2013)

Baseline Body Mass Index and the Efficacy of Hypoglycemic Treatment in Type 2 Diabetes: A Meta-Analysis
por: Cai, Xiaoling, et al.
Publicado: (2016)

Cardiac Glucolipotoxicity and Cardiovascular Outcomes
por: Cerf, Marlon E.
Publicado: (2018)

Glucolipotoxicity and GLP-1 secretion
por: Hong, Jung-Hee, et al.
Publicado: (2021)

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis
por: Prause, Michala, et al.
Publicado: (2014)

Comparisons of weight changes between sodium‐glucose cotransporter 2 inhibitors treatment and glucagon‐like peptide‐1 analogs treatment in type 2 diabetes patients: A meta‐analysis
por: Cai, Xiaoling, et al.
Publicado: (2017)

Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions
por: Krueger, Emily S., et al.
Publicado: (2021)

No disparity of the efficacy and all‐cause mortality between Asian and non‐Asian type 2 diabetes patients with sodium–glucose cotransporter 2 inhibitors treatment: A meta‐analysis
por: Cai, Xiaoling, et al.
Publicado: (2017)

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity
por: QiNan, Wu, et al.
Publicado: (2016)

Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells
por: Dahlby, Tina, et al.
Publicado: (2020)

The Adaptor Protein NumbL Is Involved in the Control of Glucolipotoxicity-Induced Pancreatic Beta Cell Apoptosis
por: Basavarajappa, Halesha D., et al.
Publicado: (2023)

Denosumab Attenuates Glucolipotoxicity-Induced β-Cell Dysfunction and Apoptosis by Attenuating RANK/RANKL Signals
por: Lin, Sheng-Chieh, et al.
Publicado: (2023)

Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling
por: Zhang, Chengshuo, et al.
Publicado: (2016)

LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis
por: Kong, Xiang, et al.
Publicado: (2019)

Clinical Implications of Urinary C-Peptide Creatinine Ratio in Patients with Different Types of Diabetes
por: Wang, Yanai, et al.
Publicado: (2019)

Analysis of Insulin Doses of Chinese Type 2 Diabetic Patients with Intensive Insulin Treatment
por: Cai, Xiaoling, et al.
Publicado: (2012)

Comparisons of the Efficacy of Alpha Glucosidase Inhibitors on Type 2 Diabetes Patients between Asian and Caucasian
por: Cai, Xiaoling, et al.
Publicado: (2013)

Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
por: Yang, Wenjia, et al.
Publicado: (2016)

CGRP and PACAP-38 play an important role in diagnosing pediatric migraine
por: Liu, Junhui, et al.
Publicado: (2022)

Liraglutide reduces hepatic glucolipotoxicity-induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats
por: Guo, Jun, et al.
Publicado: (2018)

Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by N-Acetyl Cysteine in Pancreatic β-Cells
por: Alnahdi, Arwa, et al.
Publicado: (2020)

Analysis of the Associations between Vitamin D and Albuminuria or β-Cell Function in Chinese Type 2 Diabetes
por: Cai, Xiaoling, et al.
Publicado: (2014)

Efficacy and Safety of Initial Combination Therapy in Treatment-Naïve Type 2 Diabetes Patients: A Systematic Review and Meta-analysis
por: Cai, Xiaoling, et al.
Publicado: (2018)

Baseline Triglyceride Level Affected the Efficacy of Vildagliptin in Treating Type 2 Diabetes: A Post Hoc Analysis of the VISION Study
por: Zhou, Lingli, et al.
Publicado: (2019)

Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion
por: Ward, Meliza G., et al.
Publicado: (2017)

Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes
por: Cerf, Marlon E.
Publicado: (2020)

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
por: Yang, Yiqi, et al.
Publicado: (2022)

Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate
por: Perrier, Johan, et al.
Publicado: (2023)

Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite
por: Calvó, Paula, et al.
Publicado: (2023)

Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow
por: Liu, Yulan, et al.
Publicado: (2022)

Liraglutide Attenuates Glucolipotoxicity-Induced RSC96 Schwann Cells’ Inflammation and Dysfunction
por: Kornelius, Edy, et al.
Publicado: (2022)

Sensitivity to thyroid hormone and risk of components of metabolic syndrome in a Chinese euthyroid population
por: Lv, Fang, et al.
Publicado: (2023)

Age at Diagnosis and C-Peptide Level Are Associated with Diabetic Retinopathy in Chinese
por: Cai, Xiaoling, et al.
Publicado: (2014)

Meta‐analysis and critical review on the efficacy and safety of alpha‐glucosidase inhibitors in Asian and non‐Asian populations
por: Gao, Xueying, et al.
Publicado: (2017)

Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1
por: Ren, Lei
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hobaojq6o5lmvof4i18jjpe6rp